Methanol Solution 2.5L

Methanol HPLC (CH₃OH,) is one of the most commonly used organic modifiers in reversed-phase chromatography. Although the solvent offers certain advantages and disadvantages, one of Methanol’s key strengths, from a chromatographic perspective, is that it offers substantially different selectivity, and as such, are valuable for method development purposes.

There are a range of organic solvents that are suitable for use as the organic modifier in reversed-phase liquid chromatography; in practice though, only a few are routinely used. When selecting an organic solvent, properties such as miscibility with water, polarity, UV cut-off, viscosity and safety are important to consider

Over time, methanol has become one of the organic modifiers of choice for numerous reversed-phase applications. As a solvent it is fully miscible with water and is compatible with common mobile phase additives as well as buffers (care should be taken when using buffer salts at high organic compositions).